Autologous Fibrin Glue/Sealant

Fibrin Glue

Fibrin glue can easily be made with a byproduct of the platelet-rich plasma procurement process: platelet-poor plasma (PPP).  As the name suggests, PPP is plasma with very few platelets, but is rich in plasma proteins and clotting factors.  Therefore, when combined with calcium and thrombin, it forms a gelatinous substance that can be used as a biologic glue, much like manufactured fibrin glues such as TISSEEL™, Floseal™, Coseal™.

While fibrin glue derived from PPP does not have the tensile strength of manufactured glues, it has the advantage of possessing native concentration of fibrinogen.  High concentration of fibrinogen, such as found in manufactured fibrin glues, has been shown to hinder the healing processes.

Fibrin glue made from PPP is also autologous, and therefore does not present the risk of viral transmission that some manufactured fibrin glues, which are made from the plasma of multiple human donors, carry.

 

Fibrin Sealant

Platelet-poor plasma can also be used as a sealant.  A common application is a dural sealant following neurosurgical procedures.  Again, because it is easily obtained from the patient, it is safe and inexpensive, especially when compared to manufactured sealants.